Effect of Haegan-jeon on Thioacetamide-Induced Liver Fibrosis

Objective: To investigate the protective effects of Haeganjeon on a thioacetamide (TAA)-induced liver fibrosis mouse model and to determine Haegan-jeon signaling pathway.Methods: Mice were randomly divided into 4 groups: Normal group (Nor), TAA-induced (Con), administered 50 mg/kg silymarin (S50), 200 (H200). The was established by intraperitoneal injection with TAA three times week for 8 weeks. During weeks, mice orally every day. At end study, serum collected measure levels AST, ALT, ammonia, myeloperoxidase (MPO). Liver tissue harvested analyzed western blotting Masson's trichrome staining.Results: Administration suppressed increase in MPO due fibrosis. Compared Con group, H200 showed increases antioxidant-related factors (Nrf2, HO-1, catalase, GPx-1/2) decreases inflammatory-related (NF-κB p65, p-IκB-α, Cox-2, iNOS, TNF-α, IL-1β) blots. treatment inhibited expression α-SMA Collagen I.Conclusions: hepatoprotective effect induced activation factors, such as Nrf2, it regulated inflammation response suppression NF-κB.